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A gumma is a soft, tumor-like growth of the tissues (granuloma) that occurs in people with syphilis.
A gumma is caused by the bacteria that causes syphilis. It appears during late-stage tertiary syphilis. It usually contains a mass of dead and swollen fiber-like tissue, and occurs most often in the liver. It also can occur in the:
Similar-looking sores sometimes occur with tuberculosis.
Tramont EC, Treponema pallidum (Syphilis). In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2009:chap 238.
Workowski KA, Berman S; Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010 Dec 17;59(RR-12):1-110.
Eckert LO, Lentz GM. Infections of the lower genital tract: Vulva, vagina, cervix, toxic shock syndrome, HIV infections. In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, eds. Comprehensive Gynecology. 5th ed. Philadelphia, PA: Mosby Elsevier; 2007:chap 22.