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Planning Your Trip
Business or leisure travelers who plan to visit developing or tropical countries, as well as those embarking on prolonged vacations or arduous treks, should take specific precautions:
New Vaccines In Development
More than 50 million people from industrialized nations travel to developing countries each year. Such trips can pose significant health hazards. Travelers who plan to visit developing or tropical countries, as well as those embarking on prolonged vacations, frequent trips, or arduous treks, should take a number of precautions.
It is important to see a doctor in preparation for travel to a developing nation. Since many doctors may find it hard to keep abreast of medical trends in foreign countries, a local travel clinic may be especially helpful. In addition, the Centers for Disease Control and Prevention maintains a Traveler's Health web site (www.cdc.gov/travel). The site covers news about dangerous disease outbreaks around the world, safety guidelines, and detailed information about diseases of particular concerns to travelers.
If you wear contact lenses, ask your doctor about taking along ocular (eye) antibiotics.
The following are general guidelines for vaccinations for travelers: Travelers to developing countries should check with the U.S. Centers for Disease Control, U.S. State Department, or World Health Organization for the latest information on immunization requirements at their destinations. A visit to a travel clinic will also furnish this information. Studies indicate that multiple vaccines may be given at the same time to most adults, without significantly increasing adverse effects. Only one vaccination (yellow fever) is required for US citizens for travel to parts of Africa and South America, the rest are strongly recommended.
Routine vaccinations. Adults and children should make sure routine vaccinations are up-to-date. Travelers visiting developing countries may need booster doses. Depending on a person's age, immunization history, medical condition, and travel plans, recommended vaccinations may include:
Depending upon travel destination, timing, and length of visit, some countries may require vaccinations against yellow fever, meningitis, typhoid, cholera, Japanese encephalitis, and rabies. Some of these diseases are covered in this report.
Tuberculosis: Travelers to areas with tuberculosis (TB) outbreaks should have skin tests before traveling; those with negative tests should have a repeat test 2 - 4 months after they return.
Malaria: Travelers to countries with malaria should take preventive drugs. Recommendations vary depending on destination, since resistance to different antimalaria drugs is widespread in some areas. Carried by mosquitos, there are several types of parasites which cause malaria such as Plasmodium falciparum, P. malariae, and P. vivax.
A malaria vaccine under study (against P. falciparum) has shown promise in reducing disease in Africa. Additional data on this vaccine is expected in 2014. Several other malaria vaccines are also under study, including those that may help protect a growing fetus from contracting malaria from its mother.
Immunocompromised patients: Immunocompromised patients may need to take extra precautions in addition to the recommendations in this report. Patients with a compromised immune system should discuss their travel plans with their physician.
Pregnancy: Recommendations regarding vaccination and travel medications may be different for pregnant women, and should be discussed with a physician. Pregnant women should have vaccinations appropriate to their trimester. Not all vaccinations and preventive medications are appropriate during pregnancy.
Meningococcal vaccine: A vaccine against one of the types of the bacteria that causes meningitis is recommended for travelers to areas in which the disease is common, such as sub-Saharan Africa. This vaccine is also required by the Saudi Arabian government for all travelers to Mecca during Hajj. Two types of the vaccine, MPSV4 and MCV4, are available in the United States. Children and adults under age 55 should receive the MCV4 vaccine. In the United States, all children ages 11 - 18 should receive this vaccine at the earliest opportunity, ideally between ages 11 and 12.
First aid supplies for travelers should include:
Note: Acetaminophen, the generic name for Tylenol, is known as paracetamol outside the United States.
Travelers should remember to check what coverage their health insurance company provides for policyholders abroad. Medicare does not provide coverage outside the United States, but other insurers offer limited coverage overseas. Individual supplementary health insurance policies should cost no more than a few dollars a day for international travelers. Air ambulance insurance is also a wise investment that can be purchased through travel agencies before leaving the U.S. Additionally, you may want to take along the phone number and address of the U.S. Embassy or Consulate in your destination country, in case you need the name of a doctor to contact after you arrive. While abroad, you can obtain the location of your nearest U.S. Embassy or Consulate by calling 00 1 202-501-4444.
If you develop any symptoms of illness after you return to the United States, be sure to contact your doctor immediately. Some infections can take over 30 days to develop so it is important to remind your doctor of your past travel even if it was months prior. Let your doctor know where you have been, in addition to what symptoms you are experiencing. Symptoms may include fever, rash, numbness, weakness, or yellowing of the skin.
Traveler's diarrhea (TD) is the most common health problem a traveler encounters. It is almost always caused by ingesting certain organisms in contaminated food or water. Anxiety, stress, allergies, fatigue, and dietary changes can also cause diarrhea -- particularly in children.
Diarrhea frequently occurs within the first week of travel, but it may develop at any point, even after returning home. Traveler's diarrhea causes four or five loose or watery stools per day. Vomiting may also occur. It usually lasts 3 or 4 days, but about 14% of cases last longer. In rare cases, the diarrhea lasts more than 3 months. When TD lasts a long time, it can cause post-infectious irritable bowel syndrome. Traveler's diarrhea is rarely life threatening, although it can be severely debilitating, especially in children. Weakness, reduced urine output, lightheadedness, and mental changes require immediate medical attention, especially in children. Life-threatening symptoms include reduced levels of consciousness, seizures, and coma.
Traveler's diarrhea typically affects 40 - 60% of people from industrialized nations who visit developing countries:
Several infectious organisms, including bacteria, parasites, and viruses, can cause diarrhea in travelers. These organisms are most often transmitted through contaminated food and water. Bacteria and viruses cause diarrhea within a few hours and up to 3 days, while diarrhea from parasites can occur 7 - 14 days after exposure. In about 10 - 50% of cases, the cause is unknown.
Drinking contaminated water is the most common cause of acquiring traveler's diarrhea. The following methods or products help reduce exposure to contaminated water.
Some important tips:
The following drugs can reduce your chance of getting sick:
Pepto-Bismol. Taking two tablets of Pepto-Bismol four times a day before and during travel to developing countries can help prevent many cases of diarrhea. Do not take Pepto-Bismol for more than 3 weeks. Both aspirin and Pepto-Bismol share the active ingredient salicylate, which can be harmful to children. Many medications interfere with salicylate, and people who are allergic to aspirin, pregnant women, and those with ulcers, other bleeding disorders, or gout, should not take Pepto-Bismol without consulting a doctor. Side effects of Pepto-Bismol include ringing in the ears and black stools and tongue.
Prophylactic Antibiotics. Prophylactic antibiotics are those used to prevent diarrhea while traveling. They work well, but there are many reasons that argue against their routine use. Taking prophylactic antibiotics can trigger adverse drug reactions or development of infections with resistant strains. Taking prophylactic antibiotics also contributes to the global problem of bacterial resistance. Antibiotics are also NOT effective against parasites or viruses, but their use may give travelers an unwarranted sense of security. At this time, prophylactic antibiotics are not generally recommended unless the person is at increased risk for complications of TD. People at such risk include those with chronic bowel diseases, kidney disease, diabetes, or HIV.
Lactobacilli. Taking capsules that contain protective bacteria called lactobacilli (also called probiotics) may be helpful, although the Infectious Diseases Society of American believes that evidence is insufficient to recommend them. Some studies report that a genetically engineered strain called Lactobacillus rhamnosus strain GG may prevent and reduce severity of diarrhea. In fact, lactobacilli may be used for both prevention and treatment in children without any adverse effects. The capsules can be split open and put into beverages for small children.
Fluid Replacement. If diarrhea develops, the most important steps to take are preventing dehydration and replacing lost fluids, particularly in children. In severe cases, dehydration can be life threatening. Agitation may be an early symptom of dangerous dehydration. Listlessness and a weak pulse are symptoms of severe dehydration. Parents should seek medical help immediately if the child appears to be dehydrated.
Ideally, fluid replacement utilizes solutions that contain the important minerals potassium, sodium, and calcium. The following are some suggestions:
Helpful Foods. Foods that help slow diarrhea include rice, bananas, and apples. Drinking tea is also helpful.
Adding milk (but not soy milk) to these foods may help many children. In fact, eating yogurt that contains active lactobacilli cultures may have positive benefits. (However, yogurt drinks in developing countries may carry a high risk for contamination.)
Bismuth subsalicylate (Pepto-Bismol). Pepto-Bismol can be used for treatment of mild diarrhea and nausea. Treatment generally consists of 1 fluid ounce or 2 tablets every 30 minutes for up to 8 doses in a 24-hour period. If diarrhea continues, treatment can be repeated for a second day.
Antimotility Drugs. Antimotility drugs provide prompt but temporary symptomatic relief by reducing muscle spasms in the gastrointestinal tract. They include:
Antimotility drugs should be discontinued if symptoms persist beyond 48 hours. They should NOT be used at all in patients with high fever, if there is blood in the stool, or in children under age 2. Imodium is approved for children 2 years and up, but its use in children is controversial because of reports of severe side effects. Experts do not recommend it.
Note: Lomotil and Imodium work well for treating diarrhea, but are not effective for prevention. Both drugs may even prolong the duration of illness.
Antibiotics. Antibiotics are generally effective for treating traveler's diarrhea that develops in an 8-hour period, with three or more loose stools, and especially if associated with nausea, vomiting, abdominal cramps, fever, or blood in the stools. Because antibiotics are prescription drugs, travelers at risk should obtain them before they depart and should receive directions for self-treatment while abroad. Antibiotics should not be used for nausea and vomiting when diarrhea is not present. Although self-treatment is generally safe, a doctor should be sought for any child with diarrhea and for adult patients who develop fever or bloody diarrhea. (Antibiotics are generally not useful for diarrhea in developed nations, since such cases are likely to be caused by viruses.)
In general, patients take one tablet every 12 hours for 5 days. Fluoroquinolones are the preferred antibiotic, unless the person is traveling to SE Asia or India, where bacterial resistance to this class of drugs is high. In these cases, azithromycin (Zithromax) is preferred. Taking a single dose of an antibiotic such as ofloxacin (Floxin), plus an anti-motility drug (usually Imodium), often provides relief within 24 hours for many patients. Other antibiotics used for diarrhea include ciprofloxacin (Cipro) and levofloxacin (Levaquin).
Rifaximin (Xifaxan) is another type of antibiotic that is specifically approved for the treatment of traveler's diarrhea caused by noninvasive strains of Escherichia coli, in people 12 and older. It is taken by mouth for 3 days. This medication was approved by the FDA in 2004.
Parasites do not usually respond to standard antibiotics. Trimethoprim-sulfamethoxazole (Bactrim), for example, has fallen out of favor for routine use because of resistant bacteria, but it may be very effective against the severe diarrhea caused by the parasite Cyclospora. Metronidazole (Flagyl) is the standard drug for Giardia. Erythromycin and similar antibiotics may be useful for Cryptosporidium or Campylobacter. Nitazoxanide is another antibiotic showing promise for treating diarrhea caused by parasites. Antibiotics do not work for diarrhea caused by viruses.
An estimated 15 - 45% of short-term travelers experience a health problem associated with their trip. This percentage is higher in travelers to developing countries.
A traveler can reach virtually any place in the world within 36 hours, which is less than the incubation period for most infectious diseases. The ease with which people see the world has dramatically increased the number of foreign travelers. Respiratory infections, such as influenza and colds, develop in 10 - 25% of travelers. Women traveling to the tropics are at high risk for urinary tract infections.
Even worse, doctors in Western countries are now seeing infectious diseases never before encountered in their regions. Travelers are at risk from infections transmitted among people, as well as those transmitted by insects or animals (vector-borne diseases). Malaria, which is transmitted by mosquitoes, is the most widespread vector-borne disease, and infects 300 - 500 million people around the world annually. Between 10,000 and 30,000 of these cases occur in travelers. Anyone traveling to high-risk countries should take precautions.
A Word about Bird Flu
Avian influenza type A (also known as bird flu and avian flu) is a disease causing death in more than 50% of infected persons. The virus (H5N1) is common in birds, but often does not make them appear ill. As of February 25, 2014, 658 people had been infected with the bird flu in 15 countries. Of these people, 388 have died, according to the World Health Organization. No cases have been seen in the United States. Risk factors for infection include close contact with caged birds or poultry (chickens, ducks, and turkeys), eating undercooked poultry products, and contact with poultry feces. To date, there are no documented cases of transmission of bird flu from one human to another. If they avoid these risk factors, travelers to countries with documented cases of avian flu are considered at low risk for infection. There are no travel restrictions associated with avian influenza, and preventive antiviral medications are not recommended.
Common Vector-borne Diseases
Countries of Infection
Severity and Symptoms
Treatment and Prevention
Parasite transmitted by Anopheles mosquitoes.
The world's number one infection, and nearly entirely preventable. Found in every tropical or subtropical country in the world.
Initial symptoms are flu-like, with possible nausea and vomiting. The skin may appear yellow. Without prompt treatment, can be fatal. Typically develops 10 - 30 days following exposure. Symptoms can occur up to a year or more after exposure. People who have been in malarial countries should report fever or other symptoms plus travel information to their doctor even months after they return.
Treatment: Immediate treatment is important, but the appropriate treatment depends on the traveler's destination. There is widespread resistance to standard anti-malaria drugs such as chloroquine or primaquine. Alternative drugs include quinine, atovaquone/proguanil (Malarone), doxycycline, mefloquine (Lariam), hydrochloroquine, or derivatives of artemisinin.
Prevention: Prevention should focus on minimizing exposure to mosquitoes and "mosquito-proofing" living and sleeping accommodations. Many parasites are resistant to chloroquine. Alternative drugs include atovaquone-proguanil, mefloquine, and doxycycline. Malarone causes fewer side effects than other drugs. Lariam should not be used by people with history of psychiatric disorders. Doxycycline can cause photosensitivity (skin sensitivity to light), and it cannot be taken by children or pregnant women.
Vaccines are under study.
Arbovirus transmitted by mosquito.
Nearly all cases occur in African countries near the equator and in tropical parts of South America.
Initial symptoms are usually flu-like and include headache, fatigue, fever, nausea, vomiting, and constipation. Severe symptoms include jaundice and hemorrhagic fever. Fatal in 23% of cases with severe symptoms. People who recover are immune for life.
Treatment: No exact treatment regimen for symptoms.
Prevention: Vaccination recommended before traveling to endemic areas. Vaccinations required for entry into certain countries. Vaccine not usually recommended for pregnant women, infants, nursing mothers, immunocompromised patients, or patients with history of thymus gland disease.
Less Common Vector-borne Diseases
Disease and Method of Transmission
Countries of Infection
Severity and Symptoms
Treatment and Prevention
African sleeping sickness (African Trypanosomiasis)
Parasite transmitted by tsetse fly bite.
Rural Africa, between latitudes 15 degrees N and 20 degrees S.
Symptoms may include fever, chills, headache, fluid accumulation in hands and feet, sleepiness, lethargy, and convulsions. Without treatment, the sickness is fatal.
Treatment: Pentamidine and suramin for early stages. Rimantadine under investigation. Melarsoprol or eflornithine for second stage. Nifurtimox in combination
Prevention: Flies are attracted to dark, contrasting colors. Flies are not affected by insect repellents.
Chagas' disease (American Trypanosomiasis)
Parasite transmitted by infected Reduviid bugs.
South and Central America
In the acute stage, symptoms can include a skin lesion, fever, loss of appetite, lymph node swelling, spleen and liver enlargement, and inflammation of the walls of the heart. Symptoms that may occur years or decades later include dementia, weakening of the heart, dilation of digestive tract, weight loss.
Treatment: Benznidazole and nifurtimox are usually only effective in acute attacks. Benzimidazole is also used for recurrences. Antiparasitic treatment may be recommended.
Prevention: Avoid buildings made of mud, adobe, and thatch, which can harbor the reduviid bug.
Virus transmitted by mosquitoes.
Can occur in any tropical or subtropical country. Greater risk in cities than in the country. Present in over 100 countries world-wide, putting some 2.5 billion people at risk.
High fever, severe headache, vomiting, backache, eye pain, muscle and joint pain, and occasionally a rash on the trunk and upper arms. Disease ends abruptly after 2 - 7 days. Patients usually recover, but internal bleeding and fatal hemorrhage can occur. This stage of the disease is called dengue hemorrhagic fever.
Treatment: Blood transfusions, fluids, pain killers. (Aspirin, ibuprofen, or other NSAIDs should not be used, but acetaminophen is okay.)
Prevention: No vaccine has been developed. Prevention requires protection against mosquito bites, particularly at dawn and dusk.
A number of different viruses carried by mosquitoes.
Worldwide risk although higher in some regions than others. High-risk areas include China and Korea, India, Southeast Asia.
Can be mild to life threatening. Brain swelling produces symptoms that include headache, neck stiffness, confusion, irritability, fever, weakness, dizziness, tremors, seizures, and paralysis. Serious symptoms include lethargy, delirium, coma, and even death.
Treatment: Symptomatic treatment only.
Prevention: The vaccine for Japanese encephalitis (Je-Vax) is recommended only if travelers are visiting rural areas in high-risk Asian countries for more than 30 days.
Parasitic disease transmitted by a sand fly.
Found in 88 countries around the world.
Most common forms cause skin sores and mouth and nose ulcers, sometimes disfiguring. Organ infection can involve spleen, liver, and bone marrow.
Treatment: Antimony-containing drugs (meglumine antimonate, Glucantime; sodium stibogluconate, Pentostam) for organ infection; also pentamide isethionate (Pentam 300), amphotericin B (Fungizole). Fluconazole is also effective for skin sores.
Prevention: No vaccine available.
Bacteria carried by rodents and transmitted by fleas.
Most plagues are transmitted by handling infected animals. However, the Indian pneumonic plague is airborne. Human plague reported in recent years in Africa, South East Asia, parts of South America and the US. Also reported in India, Vietnam and Zambia. Risk generally in rural mountainous areas.
Swollen and tender lymph nodes, fever, chills, headache, malaise, prostration, and gastrointestinal symptoms. Can be fatal without treatment.
Treatment: Antibiotics, particularly streptomycin. Alternatives include gentamicin, tetracyclines, and chloramphenicol.
Prevention: Use insect repellents and avoid handling any animals. Adults traveling to countries with plague outbreak may consider preventive antibiotics. Children may take sulfonamides.
Schistosoma parasitic worms live off a specific snail in fresh water contaminated with feces.
Lake swimming in sub-Saharan Africa is a particular hazard for schistosomiasis in travelers. Other countries: Brazil, Puerto Rico, St. Lucia, Egypt, Southern China, the Philippines, and Southeast Asia.
Within days, itchy skin or rash. Within 1 - 2 months, fever chills, cough, muscle aches.
Can be mild, but also can damage liver, kidneys bladder, intestines, or central nervous system.
Treatment: Praziquantel (Biltricide) or oxamniquine (Vansil). Reports of resistance have raised concern.
Prevention: Do not swim or wade in fresh water in countries where schistosomiasis occurs. Boil drinking water for 1 minute. Heat bath water to 150 °F for 5 minutes.
Nonvector-borne Bacterial or Viral Infectious Diseases Encountered by Travelers
Countries of Infection
Severity and Symptoms
Treatment and Prevention
Bacterial infection transmitted in contaminated water or food.
Outbreaks occur in many developing countries with poor sanitation. More common in warm months.
Profuse watery diarrhea, abdominal pain, and vomiting lasting 1 - 3 days. In severe cases, profound dehydration can be fatal.
Treatment: Tetracycline and oral hydration salts usually effective within 48 hours. Consume as much purified water as possible.
Prevention: Risk to travelers is considered low, and the vaccines are not produced in the U.S. or required for international travel.
Typhoid Fever and Parathyroid Fever(Enteric Fever)
Bacterial infection (salmonella typhi) in contaminated water or food. Can be spread by flies.
Can occur in any region where food or water is contaminated. Outbreaks common after natural disasters in poor countries. Tends to occur in urban areas.
Initial flu-like symptoms and low-grade fever that increases every day for a week or more. In the second stage, fever stabilizes at 103 - 104 Â°F. "Pea soup" diarrhea or constipation can develop. Untreated, disease can last up to 4 weeks and is fatal in 10% of patients. After symptoms end, the patient is still infectious.
Treatment: Antibiotics essential. Ciprofloxacin is antibiotic of choice. Fluid replacement and nutrition maintenance is critical. Even when symptoms have resolved, patients may be contagious until bacteria is eliminated.
Prevention: Vaccinations recommended for travelers visiting high-risk countries for more than four weeks. Drink bottled water. Take same precautions as for traveler's diarrhea.
Viral infection transmitted in contaminated water or food.
Worldwide. Highest risk in developing nations, particularly where sanitation is poor and cholera and typhoid are prevalent.
Nausea and vomiting, decreased appetite, itching, extreme fatigue, jaundice, fever, and abdominal pain. Serious complications are rare, but recovery may take 6 - 9 months.
Treatment: No specific treatment for acute hepatitis. Abstain from alcohol and sexual contact. Avoid dehydration. Keep own eating and cooking utensils separate from others.
Prevention: Wash hands after using the bathroom. Two vaccines are available as well as combination vaccine for hepatitis A and B. Vaccination recommended for travel to any nation where risk is intermediate or high. Immunity from vaccine may develop more slowly in elderly people. CDC recommends vaccination 4 weeks before travel. Hepatitis A vaccine is recommended for all children at age 1.
Viral infection transmitted through contaminated blood, or through sex or sharing needles with an infected person. Can be passed from cuts, scrapes, and other breaks in the skin.
Common in Southeast Asia, Africa, the Middle East, islands of the South and Western Pacific, the Amazon region of South America, and the Mediterranean.
Flu-like mild symptoms. Sometimes rash, aching in joints. Symptoms usually appear 4 - 24 weeks after exposure but can occur long after initial infection. Often no symptoms, but even patients without symptoms can remain chronically infected with the virus. Chronic infection can lead to cirrhosis, liver failure, and liver cancer.
Treatment: Treatment of symptoms.
Prevention: Several vaccines are now available, including a combination vaccine (Twinrix) for hepatitis A and B. Vaccination recommended for all children and for travelers to developing countries.
Viral infection transmitted in contaminated water or food.
Most developing countries in Africa, and parts of Asia.
Symptoms in small children can be mild and flu-like. More likely to be serious in older children and adults. Symptoms include severe fever, headache, stiff neck and back, and deep muscle pain. Can lead to paralysis and can be fatal.
Treatment: Treatments only for symptoms.
Prevention: Universal immunization required. All babies should receive vaccination as part of standard vaccine schedule, with booster at 4 -6 years of age. Booster needed for adults traveling to developing country. Inactivated polio vaccine (IPV) is used.
Bacterial infection in the fluid and membranes covering the brain and spinal cord. Spread through coughs, sneezes.
The so-called meningitis belt (countries extending across sub-Sahara Africa from Nigeria to Somalia).
Fever, chills, headache, stiff neck, rash caused by bleeding into the skin, and vomiting. Can also cause pneumonia and loss of limbs. Particularly dangerous for children.
Treatment: Early administration of antibiotics is essential.
Prevention: Vaccines (including boosters for previously vaccinated individuals) for travelers in the meningitis belt and other areas with outbreaks. Vaccine now recommended as standard for all children 11 - 12 years of age and entering college freshmen living in dorms and not previously vaccinated.
Exposure to bacteria from the urine of animals by swimming or bathing in contaminated fresh water.
Tropical and subtropical countries pose highest risk.
High fever, severe headache, diarrhea, and eye inflammation. In severe cases, can develop internal bleeding and liver and kidney damage.
Treatment: Antibiotics (as early as possible).
Prevention: Avoid water activities where leptospirosis occurs.
Severe Acute Respiratory Syndrome (SARS)
Respiratory infection caused by coronavirus. Spread by infected droplets from coughing, sneezing.
First identified in China in 2003, not currently active in any other parts of the world.
Serious form of unusual pneumonia, resulting in acute respiratory distress. Hallmark symptoms are high fever, cough, difficulty breathing, or other respiratory symptoms.
Treatment: Supportive care.
Prevention: Practice good hygiene, avoid contact with SARS patients.
Bacterial infection spread through air by coughing or sneezing. Also has been passed in unpasteurized milk.
High rates found in Africa, Asia, Central and Eastern Europe (including former Soviet Union), Latin America.
Coughing, weight loss, fever, night sweats. Can spread from lungs to central nervous system, genitourinary system, bones, and joints. Ninety percent of infected people have no symptoms.
Treatment: Multiple drugs for 6 months or longer.
Prevention: BCG vaccine available for children in developing countries. Not routinely used for travelers or US citizens. Consider screening people who return from developing countries. Isoniazid or other medications can prevent acute disease in people who are infected but not ill.
Virus transmitted from exposure to saliva from an infected animal (even from licking). Dogs are main carriers but all mammals susceptible.
Worldwide except Antarctica (some specific countries are rabies free).
Disease is nearly always fatal once symptoms develop.
Treatment: Immunoglobulins after bites, vaccine if not previously vaccinated (previously vaccinated travelers require booster vaccine, but not immunoglobulins). Clean the wound with soap and water, and iodine if possible, immediately after bite. If symptoms develop, supportive treatments only.
Prevention: Vaccine is available and recommended for travelers who intend to work with animals or are likely to come in contact with animals in countries where the rabies virus is common. Immunization does not eliminate the need for treatment after exposure to the virus.
Vector-borne diseases are infections transmitted by insects and animals that harbor parasites, viruses, or bacteria. Common vector-borne diseases include yellow fever and malaria, but there are many others in every country in the world.
The risk for malaria and other mosquito-born infections is highest when mosquitoes feed, between dusk and dawn.
DEET. Most insect repellents contain the chemical DEET (N,N-diethyl-meta-toluamide), which remains the gold standard of currently available mosquito and tick repellents. DEET has been used for more than 40 years and is safe for most children when used as directed. Comparison studies suggest that DEET preparations are the most effective insect repellents now available.
DEET concentrations range from 4 - 100%. The concentration determines the duration of protection. Experts recommend that most adults and children over 12 years old use preparations containing a DEET concentration of 20 - 35% (such as Ultrathon), which provides complete protection for an average of 5 hours. (Higher DEET concentrations may be necessary for adults who are in high-risk regions for prolonged periods.)
DEET products should never be used on infants younger than 2 months. According to the Environmental Protection Agency (EPA), DEET products can safely be used on all children age 2 months and older. The EPA recommends that parents check insect repellant product labels for age restrictions. If there is no age restriction listed, the product is safe for any age. The American Academy of Pediatrics recommends that children use 10-30% DEET concentrations. In deciding what level of concentration is most appropriate, parents should consider the amount of time that children will be spending outside, and the risk of mosquito bites and mosquito-borne disease.
When applying DEET, the following precautions should be taken:
Other Insect Repellent Products. In 2005, the U.S. Centers for Disease Control and Prevention (CDC) added two new mosquito repellents to its list of recommended products: Picaridin and oil of lemon eucalyptus. Picaridin, also known as KBR 3023 or Bayrepel, is an ingredient that has been used for many years in repellents sold in Europe, Latin America, and Asia. Picardin in concentrations of 5 - 10% is now available in the U.S. Picaridin can safely be applied to young children and is also safe for women who are pregnant or breastfeeding. According to the CDC, insect repellents containing DEET or picaridin work better than other products. In scientific tests, oil of lemon eucalyptus, also known as PMD, worked as well as low concentrations of DEET. However, oil of lemon eucalyptus is not recommended for children under the age of 3 years.
Use of Permethrin. Permethrin is an insect repellent used as a spray for clothing and bed nets, which can repel insects for weeks when applied correctly. Electric vaporizing mats containing permethrin may be very helpful. A permethrin solution is also available for soaking items, but it should never be applied to the skin. Side effects from direct exposure may include mild burning, stinging, itching, and rash, but in general, permethrin is very safe and its use may even reduce child mortality rates from malaria. Travelers allergic to chrysanthemum flowers or who are allergic to head-lice scabicides should avoid using permethrin.
Other Preventive Measures Against Insect-borne Diseases:
Burning citronella candles reduces the likelihood of bites. (Indeed, burning any candle helps to some extent, perhaps because the generation of carbon dioxide diverts mosquitoes toward the flame.) Smoke from burning certain plants, including ginger, beetlenut, and coconut husks, may also reduce mosquito infiltration, but the irritating and toxic effects on the eyes and lungs (such as with the citrosa plant) may be considerable.
About a third of the population is susceptible to motion sickness, with varying degrees of severity. The cause of motion sickness is still unclear. Some evidence suggests that, in susceptible people, motion triggers signals that the brain interprets as being in conflict with the brain's memory of correct position. It transmits this message to other parts of the body, which respond with sweating, nausea, salivating, and other symptoms of motion sickness. Other theories suggest that motion sickness is triggered by the body's inability to control its own posture and movement.
More women than men experience motion sickness. Women appear to be at higher risk just before and during menstruation. Motion sickness may also trigger migraines, even in people who do not ordinarily have them. Alcohol intake increases the risk of vomiting. The following are some remedies tried for motion sickness:
Medications. Prescribed medications include scopolamine as a patch (Transderm Scop), which is worn behind the ear and releases the drug slowly. Scopolamine is the most effective drug for motion sickness.
Over-the-counter medications include dimenhydrinate (Dramamine), meclizine (Bonine), and cyclizine (Marezine). Dramamine appears to be the most rapidly effective, although in one study Marezine caused less drowsiness and was more effective at reducing nausea after 3 minutes. None of these medications are as effective as prescription drugs but may be helpful for 6 - 12 hours. To ensure the drug achieves its desired effect, take oral medications at least an hour before traveling.
Nearly all the medications used for motion sickness, both prescription and nonprescription, can cause drowsiness, mouth dryness, and blurred vision. Scopolamine can cause heart rhythm disturbances. In one comparison study the scopolamine patch had the fewest adverse effects on functioning, while dimenhydrinate had the most.
Non-medicinal Treatments. Common recommendations include focusing the eyes on the horizon (not on nearby areas), and avoiding alcohol and strong odors. Non-medicinal or alternative remedies are widely used, but are of unproven benefit. Some methods that have been tried include:
Effects on Circulation. Traveling by car, airplane, or train for more than four hours increases the risk for blood clots in the legs (deep vein thrombosis, also known as DVT) in anyone. Those at highest risk include people with cardiovascular disease or its risk factors, people who have had recent surgery, cancer patients, and those taking oral contraceptives. Studies now suggest that DVT is the cause of more deaths than previously believed, because symptoms typically occur days after travel. In order to keep circulation moving during international flights or on trains, travelers should drink plenty of fluids, avoid salt, wear slippers, wear clothing that fits loosely in the waist and legs, take frequent walks in the aisles, and lift their legs up and down several times an hour. Major reviews of existing studies suggest that special stocking that compress the calves and ankles (such as Kendall Travel Socks, Sigvaris Traveno) may prevent swelling and blood clots due to long flights, even in travelers at medium to low risk.
Respiratory Infections. Flight cabins have very low humidity, which not only increases the risk for dehydration and dry eyes, but it also increases the risk for triggering disease in the airways. Fliers with colds or allergies are especially susceptible. The first rule is to drink plenty of liquids. Taking a decongestant tablet or nasal spray (not one containing an antihistamine) 30 minutes before flight can help prevent sinus and ear infections.
Of greater concern are studies suggesting that the prolonged time (8 hours or more) spent in the confined space of an airplane, combined with the close proximity to passengers from around the world, may facilitate the spread of serious contagious diseases such as tuberculosis. The CDC and World Health Organization now have guidelines on when and how to determine the need for preventive treatments after possible exposure to infectious organisms. (Recirculated air, which is now common in new aircraft, does not increase the risk for respiratory infections.)
Preventing Jet Lag. Crossing time zones can throw off the body's natural rhythms, especially when travelers fly from west to east. Jet lag can cause excessive daytime sleepiness and insomnia at night and mood changes. It can affect concentration and energy levels. Jet lag can make it difficult to enjoy your stay or readjust once you get home. But jet lag can be minimized. A few days before long flights, adjust sleeping and eating patterns:
Melatonin, a natural hormone associated with light changes, may help people recover from jet lag. Some people report good results by taking it on the day of departure a half hour before the expected sleeping time in the arrival city. Travelers might also ask their doctors about short-acting benzodiazepines ("sleeping pills") such as lorazepam (Ativan); benzodiazepine-receptor agonists such as zolpidem (Ambien) or eszopiclone (Lunesta); alprazolam (Xanax); or temazepam (Restoril). Note that these drugs have been known to cause short-term forgetfulness and other side effects, and should be tested out at home before traveling.
When you arrive, follow the local eating and sleeping patterns as much as possible. Take short 20-30 minute naps if you need to. Stay outside during the day so that your body recalibrates day vs night time.
Every year, millions of US workers travel overseas for business. International business travelers may be at increased risk of illness due to:
Even without a full 4-6 week notice, international business travelers should still visit with their doctor for advice and vaccinations. Some vaccinations can be administered on a shortened schedule. Business travelers should follow the precautions and jetlag advice above, particularly if meetings are scheduled soon after arrival. If possible, important meetings should be scheduled days after you arrive so that you have had time to adjust. If you are in a rush, ask family, friends, and co-workers if they have a travel first aid/health kit.
Reports of illnesses aboard cruise ships, particularly gastrointestinal problems from contaminated food, have alarmed many travelers. A sanitation program conducted by the U.S. Public Health Service should significantly cut the risk for such problems. Cruise ships are inspected twice a year and are then rated. The CDC provides ratings to the public for all ships sailing from U.S. ports. At this time the ratings are the only guide for a healthy cruise. Meanwhile, cruise-ship travelers should avoid eating undercooked eggs and shellfish to help protect against diarrhea.
Aside from sanitation, health problems in general are common on cruise ships. A study of one major cruise ship reported that nearly 30% of the passengers were treated for skin disorders and 26% for respiratory problems while on board. The highly contagious norovirus, brought on board by one passenger, can quickly spread throughout the ship. Flu outbreaks sometimes occur even in summer. Older people who have not been immunized during the flu season preceding
their cruise should ask their doctor about flu vaccinations. They add no value for people who had been immunized during the flu season immediately preceding their cruise.
An estimated 3 - 10% of travelers experience some skin problem related to their trip, particularly when traveling to tropical and subtropical areas.
Avoiding Excessive Exposure to Sunlight. Many developing countries are in the tropics, were sunlight is intense. Ultraviolet radiation from sunlight not only can cause sunburn, but excessive sunlight and heat can cause toxic skin reactions in susceptible individuals. Everyone should avoid episodes of excessive sun exposure, particularly during the hours of 10 a.m. to 4 p.m., when sunlight pours down 80% of its daily dose of damaging ultraviolet radiation. Reflective surfaces like water, sand, concrete, and white-painted areas should be avoided. Clouds and haze are not protective. High altitudes increase the risk for burning in shorter time, compared to sea level and lower altitudes. Sunscreens and sunblocks with an SPF of 15 or higher are important and should be used generously. However, they should not be relied on for complete protection. Wearing sun-protective clothing is equally important, and provides even better protection than sunscreens. Everyone, including children, should wear hats with wide brims.
Preventing Skin Infections. People who visit the tropics or developing regions are at risk for a number of skin disorders, including infections with fungi and other organisms. Cleanliness is essential. Bathing or showering is very beneficial, but if there are no facilities, simply washing with soap and water (even if cold) is still helpful. (Note: Taking multiple daily showers can remove protective oils and is not recommended.)
The skin should also be kept dry in order to prevent fungal infections, which thrive in damp, warm climates. Take special care to clean and keep dry certain skin areas where infections are most likely to occur. They include creases in the skin, the armpits, the groin, buttocks, and areas between the toes. Use talcum powder in these areas. Keep socks dry.
Acute high altitude illness, or mountain sickness, can affect the brain (cerebral edema), the lungs (pulmonary edema), or both. Studies suggest that about 25% of mountain climbers experienced symptoms at 7,000 - 9,000 feet, and 42% of them have symptoms at 10,000 feet. Rapid ascension to high altitude, such as arrival by airplane, increases the risk. In most cases the condition is mild. Severe lack of oxygen at high altitudes, however, can cause serious problems in some people.
Luckily, symptoms of the more severe complications come on slowly, are easily recognized, and resolve when returning to a lower altitude.
Risk Factors for High Altitude Sickness. The risk for high altitude sickness is determined by certain characteristics: The rate at which a person ascends; the altitude reached; altitude during sleep; and individual physiology. People who live yearlong at low altitudes are much more likely to be ill at greater heights. Being physically stronger is not protective. Certain common conditions (heart disease, diabetes, hypertension, mild emphysema, and pregnancy) play no role in a person's risk for high altitude sickness. (Upper respiratory infections, however, do increase the risk for HAPE.)
Precautions against Mountain Sickness. Acclimatization by staying several days at increasingly higher altitudes is recommended. If you take high blood pressure medication, ask your doctor about increasing dosage if traveling to high altitudes. And anyone with a chronic medical condition should check with his or her doctor.
The following are some measures for preventing mountain sickness.
Medications Preventing and Managing Mountain Sickness. Some medications are available for prevention or treatment of acute mountain sickness.
Travelers planning to descend rather than ascend must also take precautions. Individuals with the following conditions should not scuba dive:
Diving, in fact, is becoming known as a cause of many types of headaches, and anyone with a history of chronic or frequent headaches should discuss these issues with a health professional familiar with this sport.
Avoiding Air Embolism. Air embolisms are bubbles that obstruct blood vessels and can occur in divers who hold their breath while swimming up to the surface. They can be life threatening and cause long-term neurologic impairment, including memory lapses, impaired thinking, and emotional disorders. Even tiny bubbles may do some harm over time. One study found that in amateur divers who dive frequently, tiny bubbles appeared to increase the risk for small brain lesions and degenerating spinal disks.
To eliminate these bubbles, experts recommend that you:
Drowning. The other major cause of scuba diving deaths is drowning in underwater caves due to improper training and poor equipment.
People with diabetes who do not require insulin injections do very well during international travel, provided they monitor diet and exercise. Insulin-dependent patients should remember that if they are traveling eastward the first day is shortened, and they may need less insulin. Westward travel means a longer day, thus may require additional insulin. Patients who travel by aircraft and need to carry syringes or needles now require medical documents.
People with any serious medical conditions should check with their doctor before travel. Of note, cabin pressure in aircraft is typically equal to about 5,000 - 8,000 feet above sea level. This can produce a 4% reduction of oxygen in the blood, which can affect patients with heart or lung problems.
Recommendations for Patients with Heart Risks. One study reported that over half the deaths that occurred in overseas travelers were due to heart disease. Generally, the following recommendations may be useful for travelers with a history of heart disease. Individual conditions vary, however, and any patient with heart disease, particularly a history of heart attack, should check with a doctor before traveling.
Recommendations for Patients with Lung Disease. The following are some recommendations for patients with lung disease:
Updated British Thoracic Society recommendations for air travel in patients with stable respiratory disease are available. The recommendations include specific areas of importance for pre-flight assessment in children and adults with stable respiratory disease, as well as disease-specific recommendations.
Organ transplant recipients comprise another distinct group of overseas travelers. They may be at increased risk for illness and infection. Transplant and travel providers can assess travel plans and unique health risks. Some live vaccinations are contraindicated after solid organ transplant. If possible, it is best to receive recommended vaccinations before the transplant. Medications for malaria and traveler’s diarrhea may interact with transplant medications.
Pregnancy alters a woman's immune system. Before traveling to any country with health risks, pregnant women should note the following:
Concerning air travel, pregnant women should consider the following:
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